Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC006
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-29 14:20
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl+/ Madopar 250mg 1/2+1/4+1/2 caps Madopar HBS 125mg 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 9 individuals with a value less than 0.54 were subsequently diagnosed with PD. That is, 21.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.54 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 6, 'TN': 7, 'TP': 36, 'FP': 23}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.196
timePerCircleCoV 0.152147
timePerCircleSlope 0.0254078
meanError 2.08807
tremorFreq 5.66406
tremorRelPower 49.0084
tremorGyroAmpMean 0.0210232
tremorGyroAmpSlope -0.00092296
tremorGyroAmpCoV 0.423756
tremorCoordAmpMean 0.0460739
tremorCoordAmpSlope -0.000169139
tremorCoordAmpCoV 0.287059
tremorAccAmpMean 0.0856696
tremorAccAmpSlope -0.00134948
tremorAccAmpCoV 0.0914392
tremorPcRelVar 0.61289
tremorPcX 0.674749
tremorPcY 0.738047

Circle Segment 1

Duration 8.4 s, Accuracy Estimate 2.135 (lower is better)

Circle Segment 2

Duration 8.52 s, Accuracy Estimate 3.08 (lower is better)

Circle Segment 3

Duration 7.0 s, Accuracy Estimate 1.875 (lower is better)

Circle Segment 4

Duration 7.08 s, Accuracy Estimate 1.809 (lower is better)

Circle Segment 5

Duration 7.04 s, Accuracy Estimate 1.797 (lower is better)

Circle Segment 6

Duration 8.04 s, Accuracy Estimate 1.744 (lower is better)

Circle Segment 7

Duration 7.8 s, Accuracy Estimate 1.668 (lower is better)

Circle Segment 8

Duration 7.48 s, Accuracy Estimate 2.195 (lower is better)

Circle Segment 9

Duration 10.68 s, Accuracy Estimate 2.128 (lower is better)

Circle Segment 10

Duration 9.92 s, Accuracy Estimate 2.449 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 27.2743
timePerSpiralCoV 0.105037
timePerSpiralSlope 0.0291221
meanError 2.37155
tremorFreq 5.56641
tremorRelPower 13.8959
tremorGyroAmpMean 0.0277212
tremorGyroAmpSlope 0.00135731
tremorGyroAmpCoV 0.463708
tremorCoordAmpMean 0.0915301
tremorCoordAmpSlope -0.00298734
tremorCoordAmpCoV 2.36817
tremorAccAmpMean 0.0546352
tremorAccAmpSlope 0.00063796
tremorAccAmpCoV 0.245618
tremorPcRelVar 0.690818
tremorPcX 0.00313152
tremorPcY -0.999995

Spiral Segment 1

Duration 24.88 s, Accuracy Estimate 2.17 (lower is better)

Spiral Segment 2

Duration 29.32 s, Accuracy Estimate 2.733 (lower is better)

Spiral Segment 3

Duration 24.28 s, Accuracy Estimate 2.79 (lower is better)

Spiral Segment 4

Duration 23.88 s, Accuracy Estimate 2.723 (lower is better)

Spiral Segment 5

Duration 28.32 s, Accuracy Estimate 2.331 (lower is better)

Spiral Segment 6

Duration 29.24 s, Accuracy Estimate 2.08 (lower is better)

Spiral Segment 7

Duration 31.0 s, Accuracy Estimate 1.773 (lower is better)

Elel

eDurationMean 0.367424
eDurationStd 0.119818
eDurationStdnorm 0.326104
eDurationMedian 0.335
eDurationQuartdelta 0.0525
eDurationQuartdeltanorm 0.156716
eDurationKurt 12.6535
eDurationTrenddiff -0.0125
eDurationTrendratio 0.963768
eWidthMean 3.38236
eWidthStd 0.882538
eWidthStdnorm 0.260923
eWidthMedian 3.276
eWidthQuartdelta 1.08225
eWidthQuartdeltanorm 0.330357
eWidthKurt 3.36931
eWidthTrenddiff 0.5265
eWidthTrendratio 1.18367
eHeightMean 6.01309
eHeightStd 1.91603
eHeightStdnorm 0.318643
eHeightMedian 5.616
eHeightQuartdelta 1.5795
eHeightQuartdeltanorm 0.28125
eHeightKurt 14.9412
eHeightTrenddiff 0.7605
eHeightTrendratio 1.14607
eAspectMean 0.577757
eAspectStd 0.128305
eAspectStdnorm 0.222075
eAspectMedian 0.578947
eAspectQuartdelta 0.173478
eAspectQuartdeltanorm 0.299643
eAspectKurt 3.76268
eAspectTrenddiff 0.0796377
eAspectTrendratio 1.15254
eSlantMean 0.162506
eSlantStd 0.148293
eSlantStdnorm 0.912533
eSlantMedian 0.145833
eSlantQuartdelta 0.203531
eSlantQuartdeltanorm 1.39564
eSlantKurt 2.47577
eSlantTrenddiff -0.0831619
eRtopMean 0.799461
eRtopStd 0.136098
eRtopStdnorm 0.170238
eRtopMedian 0.833333
eRtopQuartdelta 0.150007
eRtopQuartdeltanorm 0.180008
eRtopKurt 4.6287
eRtopTrenddiff -0.022619
eRbotMean 0.537159
eRbotStd 0.188096
eRbotStdnorm 0.350169
eRbotMedian 0.5
eRbotQuartdelta 0.288034
eRbotQuartdeltanorm 0.576068
eRbotKurt 2.7939
eRbotTrenddiff -0.017462
eRrightMean 0.91914
eRrightStd 0.0591666
eRrightStdnorm 0.0643717
eRrightMedian 0.927273
eRrightQuartdelta 0.103995
eRrightQuartdeltanorm 0.112151
eRrightKurt 2.65778
eRrightTrenddiff -0.0291369
eRleftMean 0.353801
eRleftStd 0.116472
eRleftStdnorm 0.329201
eRleftMedian 0.345455
eRleftQuartdelta 0.172056
eRleftQuartdeltanorm 0.498057
eRleftKurt 2.17863
eRleftTrenddiff -0.0258658
lDurationMean 0.448971
lDurationStd 0.0931664
lDurationStdnorm 0.207511
lDurationMedian 0.43
lDurationQuartdelta 0.09
lDurationQuartdeltanorm 0.209302
lDurationKurt 3.71999
lDurationTrenddiff -0.025
lDurationTrendratio 0.94382
lWidthMean 7.20238
lWidthStd 1.67362
lWidthStdnorm 0.232371
lWidthMedian 7.0785
lWidthQuartdelta 2.574
lWidthQuartdeltanorm 0.363636
lWidthKurt 2.49901
lWidthTrenddiff 0.117
lWidthTrendratio 1.01667
lHeightMean 12.8012
lHeightStd 2.39157
lHeightStdnorm 0.186824
lHeightMedian 12.3435
lHeightQuartdelta 3.51
lHeightQuartdeltanorm 0.28436
lHeightKurt 2.37343
lHeightTrenddiff -0.702
lHeightTrendratio 0.943925
lAspectMean 0.569773
lAspectStd 0.129334
lAspectStdnorm 0.226992
lAspectMedian 0.545869
lAspectQuartdelta 0.153575
lAspectQuartdeltanorm 0.281341
lAspectKurt 3.50782
lAspectTrenddiff 0.0882112
lAspectTrendratio 1.17957
lSlantMean 0.410264
lSlantStd 0.131488
lSlantStdnorm 0.320497
lSlantMedian 0.39017
lSlantQuartdelta 0.172844
lSlantQuartdeltanorm 0.442997
lSlantKurt 5.28692
lSlantTrenddiff 0.0960908
lRtopMean 0.9273
lRtopStd 0.0574499
lRtopStdnorm 0.0619539
lRtopMedian 0.939976
lRtopQuartdelta 0.0766917
lRtopQuartdeltanorm 0.081589
lRtopKurt 2.69098
lRtopTrenddiff 0.0182796
lRbotMean 0.215237
lRbotStd 0.0996813
lRbotStdnorm 0.463123
lRbotMedian 0.188095
lRbotQuartdelta 0.143981
lRbotQuartdeltanorm 0.765469
lRbotKurt 2.11818
lRbotTrenddiff 0.00865801
lRrightMean 0.973714
lRrightStd 0.0258666
lRrightStdnorm 0.0265649
lRrightMedian 0.980181
lRrightQuartdelta 0.030099
lRrightQuartdeltanorm 0.0307076
lRrightKurt 3.9678
lRrightTrenddiff 0.00360144
lRleftMean 0.130172
lRleftStd 0.0860593
lRleftStdnorm 0.661119
lRleftMedian 0.123248
lRleftQuartdelta 0.0952381
lRleftQuartdeltanorm 0.772738
lRleftKurt 10.4804
lRleftTrenddiff -0.0100125

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.932204
sumTouchScores 10.2542
meanMovementTime 1.5805
numTouches 11
undershootPercentage 0
overshootPercentage 18.1818

FITTS Long Modified

meanTouchScore 0.791202
sumTouchScores 7.12082
meanMovementTime 1.60188
numTouches 9
undershootPercentage 0
overshootPercentage 77.7778

ZigZag

numZigzags 4
timePerZigzagMean 33.93
timePerZigzagCoV 0.171303
timePerZigzagSlope -0.0279399
meanError 3.17563
tremorFreq 6.25
tremorRelPower 26.5672
tremorGyroAmpMean 0.0228269
tremorGyroAmpSlope 0.00050596
tremorGyroAmpCoV 0.346352
tremorCoordAmpMean 0.0963304
tremorCoordAmpSlope -0.00577984
tremorCoordAmpCoV 1.93823
tremorAccAmpMean 0.0787945
tremorAccAmpSlope 9.46515e-05
tremorAccAmpCoV 0.0984089
tremorPcRelVar 0.954273
tremorPcX -0.32705
tremorPcY -0.945007

ZigZag Segment 1

Duration 31.64 s, Accuracy Estimate 2.575 (lower is better)

ZigZag Segment 2

Duration 36.44 s, Accuracy Estimate 3.393 (lower is better)

ZigZag Segment 3

Duration 40.52 s, Accuracy Estimate 3.347 (lower is better)

ZigZag Segment 4

Duration 27.12 s, Accuracy Estimate 3.387 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.256
timePerZigzagCoV 0.283508
timePerZigzagSlope -0.159796
zigzagHeightMean 75.2507
zigzagHeightCoV 0.0984565
zigzagHeightSlope 0.0543157
meanError 0.0472917
tremorFreq 5.46875
tremorRelPower 21.8614
tremorGyroAmpMean 0.0413651
tremorGyroAmpSlope -0.0024587
tremorGyroAmpCoV 0.389923
tremorCoordAmpMean 0.0873511
tremorCoordAmpSlope 0.00157298
tremorCoordAmpCoV 0.428278
tremorAccAmpMean 0.0656254
tremorAccAmpSlope 0.000489468
tremorAccAmpCoV 0.441161
tremorPcRelVar 0.828223
tremorPcX 0.227483
tremorPcY -0.973782

ZigZag Offset Segment 1

Duration 35.68 s, Accuracy Estimate 0.08 (lower is better)

ZigZag Offset Segment 2

Duration 24.32 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 3

Duration 21.68 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 4

Duration 22.28 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 5

Duration 17.32 s, Accuracy Estimate 0.06 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.33}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.54}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.509502157286164}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9313673972419143}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6672511569026484}